Hovsepyan LM
Institute of Molecular biology NAS of Armenia, Armenia
Title: Specifities of glycolipids metabolizm in rat and lipid peroxidation during aging
Biography
Biography: Hovsepyan LM
Abstract
Oxidative processes and lipid metabolism were studied in young (4–5 months) and old (25–28 months) rats. The increased rate of lipid peroxidation (hydroperoxides, malondialdehyde, nitric oxide), as well as the accumulation of products of the oxidative modification of proteins, was observed in the mitochondrial fraction of rat brain tissues. The study of lipid diversity in brain tissues of old rats demonstrated that aging is accompanied by changes in the qualitative and quantitative phospholipid composition. It was found that changes in the metabolism of neutral glycolipids result in a decrease in the expression of cerebrosides and sulfatides. Also, an increase was observed in the sphingosine level (a product of hydrolysis of neutral glycolipids). It was shown that disorders in lipid metabolism play a key role in pathological changes during aging. Thus, the data we obtained on changes in oxidation and lipid metabolism can be useful for better understanding the mechanisms of aging.