Ping Song
Georgia State University, USA
Biography
Dr. Ping Song has a broad background in cell biology and biochemistry with specific training and expertise in both vascular biology and metabolism. By developing effective cell and mouse animal models, Dr. Song’s researches are focused on vascular biology and remodeling under aging, diabetic, or tobacco smoking/and e-cigarette condition. Recently, Dr. Song’s lab reported that activation of adenosine monophosphate-activated protein kinase (AMPK), an energy gauge and redox sensor, delays aging process by reduction of cyclin-dependent kinase (CDK) inhibitor p16 that is mediated by HMG box-containing protein 1 (HBP1). AMPKα2 isoform plays a fundamental role in anti-oxidant stress and anti-senescence. AMPKα also plays an important role in maintaining chromosome integrity and reduction of DNA damage, which is highly associated with cellular senescence. Ketone body β-hydroxybutyrate exerts anti-aging effects in both endothelial and vascular smooth muscle cells by upregulating a heterogeneous nuclear ribonucleoprotein A1-controlled Oct4-mediated Lamin B1 signaling pathway.